ODCs

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Takayasu arteritis

1 OMIM reference -
3 associated genes
41 signs/symptoms

PROTEIN INTERACTIONS: 1
COMMON SIGNS: 4

Hereditary cerebral hemorrhage with amyloidosis, Italian type

1 OMIM reference -
1 associated gene
7 signs/symptoms

Takayasu arteritis

Hereditary cerebral hemorrhage with amyloidosis, Italian type

HLA-B	(UniProt - OMIM)	APP	(UniProt - OMIM)
IL12B	(UniProt - OMIM)
MLX	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MLX	(0.56)	APP

Citations in the biomedical literature:

Takayasu arteritis		Hereditary cerebral hemorrhage with amyloidosis, Italian type
	Synonym(s): (no synonyms)		Synonym(s): - HCHWA, Italian type

	Classification (Orphanet): - Rare circulatory system disease - Rare renal disease - Rare systemic or rheumatologic disease		Classification (Orphanet): - Rare genetic disease - Rare neurologic disease - Rare systemic or rheumatologic disease

	Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: adulthood Average age of death: - Type of inheritance: sporadic		Epidemiological data: (no data available)

	External references: 1 OMIM reference - 1 MeSH reference: D013625		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Facial pain / cephalalgia / migraine - Obnubilation / coma / lethargia / desorientation - Seizures / epilepsy / absences / spasms / status epilepticus - Transient cerebral ischemia / stroke

Takayasu arteritis		Hereditary cerebral hemorrhage with amyloidosis, Italian type
	Very frequent - Acute arterial hypertension / hypertensive crisis - Acute ischemic syndrome - Arterial aneurism (excluding aorta) - Arterial pulse abolition - Arterial stenosis / occlusion - Asthenia / fatigue / weakness - Cardiac valvulopathy - Fever / chilling - Hyperhidrosis / increased sweating - Subcutaneous nodules / lipomas / tumefaction / swelling - Vascularitis / vasculitides / arteritis - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Anaemia - Angor pectoris / myocardial infarction - Anorexia - Aortic root dilatation / dilation / aneurysm - Aortic valve atresia / stenosis / narrowing / supra-aortic / supra-valvular stenosis - Arthritis / synovitis / synovial proliferation - Biological inflammatory syndrome / increased erythrocyte sedimentation rate / CRP - Cardiomyopathy / hypertrophic / dilated - Chronic arterial hypertension - Chronic skin infection / ulcerations / ulcers / cancrum - Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis - Gangrena / necrosis - Muscle weakness / flaccidity - Myalgia / muscular pain - Pulmonary hypertension - Respiratory rhythm disorder - Thoracic / chest pain - Visual loss / blindness / amblyopia Occasional - Articular / joint pain / arthralgia - Endocardium anomalies / fibroelastosis / endocarditis - Hemoptysis - Mesenteric / intestinal infarction - Retinopathy - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia - Transient amaurosis / acute visual trouble		Very frequent - Autosomal dominant inheritance - Intracranial / cerebral / meningeal hemorrhage Frequent - Psychic / psychomotor regression / dementia / intellectual decline